The near-surface currents have been observed during last thirty years using Lagrangian drifter in the whole Mediterranean Sea. The Mediterranean Surface Velocity Programme (MedSVP) dataset collects all drifter data from various institutions and countries since 1986. The connection between the central Mediterranean and surrounding areas in the period 1986 – 2016 has been studied by looking at the statistical properties of drifter trajectories. In particular, we investigated the connection with a selected set of target boxes identified on the basis of: a) Distribution of data, i.e. data coverage and density. b) Surface circulation pattern, with a particular focus on the dynamic structures of interest (e.g. the Mid Ionian Jet in the Ionian Sea, etc.) c) Socio-economic importance of the area, i.e. presence of AMPs, areas of tourist importance, etc. An application of the connectivity methodology, has been applied for the Adriatic-Ionian Bimodal Oscillating System (BiOS) phases, showing their effect on the connectivity of the central Mediterranean Sea.